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Proceedings Paper

Single LED-based device to perform widefield fluorescence imaging and photodynamic therapy
Author(s): Clovis Grecco; Hilde H. Buzzá; Mirian D. Stringasci; Cintia T. Andrade; Jose D. Vollet-Filho; Sebastião Pratavieira; Anderson L. Zanchin; Aparecida M. Tuboy; Vanderlei S. Bagnato
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Paper Abstract

Photodynamic therapy (PDT) is a treatment modality that can be indicated for several cancer types and pre-cancer lesions. One of the main applications of PDT is the treatment of superficial skin lesions such as basal cell carcinoma, Bowen’s disease and actinic keratosis. Three elements are necessary in PDT, a photosensitizer (PS); light at specific wavelength to be absorbed by the PS, and molecular oxygen. A typical PS used for skin lesion is protoporphyrin IX (PpIX), which is an intrinsic PS; its production is stimulated by a pro-drug, such as 5-aminolevulinic acid (ALA). Before starting a treatment, it is very important to follow up the PpIX production (to ensure that enough PS was produced prior to a PDT application) and, during a PDT session, to monitor its photodegradation (as it is evidence of the photodynamic effect taking place). The aim of this paper is to present a unique device, LINCE (MMOptics - São Carlos, Brazil), that brings together two probes that can, respectively, allow for fluorescence imaging and work as a light source for PDT treatment. The fluorescence probe of the system is optically based on 400 nm LED (light emitting diodes) arrays that allow observing the fluorescence emission over 450 nm. The PDT illumination probe options are constituted of 630 nm LED arrays for small areas and, for large areas, of both 630 nm and 450 nm LED arrays. Joining both functions at the same device makes PDT treatment simpler, properly monitorable and, hence, more clinically feasible. LINCE has been used in almost 1000 PDT treatments of superficial skin lesions in Brazil, with 88.4% of clearance of superficial BCC.

Paper Details

Date Published: 19 June 2015
PDF: 10 pages
Proc. SPIE 9531, Biophotonics South America, 953121 (19 June 2015); doi: 10.1117/12.2185925
Show Author Affiliations
Clovis Grecco, Univ. of São Paulo (Brazil)
Hilde H. Buzzá, Univ. of São Paulo (Brazil)
Mirian D. Stringasci, Univ. of São Paulo (Brazil)
Cintia T. Andrade, Univ. of São Paulo (Brazil)
Jose D. Vollet-Filho, Univ. of São Paulo (Brazil)
Sebastião Pratavieira, Univ. of São Paulo (Brazil)
Anderson L. Zanchin, MMOptics Ltda. (Brazil)
Aparecida M. Tuboy, MMOptics Ltda. (Brazil)
Vanderlei S. Bagnato, Univ. of São Paulo (Brazil)


Published in SPIE Proceedings Vol. 9531:
Biophotonics South America
Cristina Kurachi; Katarina Svanberg; Bruce J. Tromberg; Vanderlei Salvador Bagnato, Editor(s)

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