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Proceedings Paper

Dynamic speckle-interferometer for intracellular processes analyses at high optical magnification
Author(s): A. A. Baharev; A. P. Vladimirov; A. S. Malygin; Y. A. Mikhailova; I. A. Novoselova; D. I. Yakin; A. V. Druzhinin
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Paper Abstract

At present work dynamic of biospeckles is used for studying processes occurring in cells which arranged in the one layer. The basis of many diseases is changes in the structural and functional properties of the molecular cells components as caused by the influence of external factors and internal functional disorders. Purpose of work is approbation of speckle-interferometer designed for the analysis of cellular metabolism in individual cells. As a parameter, characterizing the metabolic activity of cells used the value of the correlation coefficient (η) of optical signals proportional to the radiation intensity I, recorded at two points in time t. At 320x magnification for the cell diameter of 20 microns value η can be determined in the area size of 6 microns.

Paper Details

Date Published: 22 June 2015
PDF: 9 pages
Proc. SPIE 9529, Optical Methods for Inspection, Characterization, and Imaging of Biomaterials II, 95291G (22 June 2015); doi: 10.1117/12.2184622
Show Author Affiliations
A. A. Baharev, Ural Federal Univ. (Russian Federation)
A. P. Vladimirov, Ural Federal Univ. (Russian Federation)
A. S. Malygin, Ural Federal Univ. (Russian Federation)
Y. A. Mikhailova, Ural Federal Univ. (Russian Federation)
I. A. Novoselova, Ural Federal Univ. (Russian Federation)
D. I. Yakin, Ural Federal Univ. (Russian Federation)
A. V. Druzhinin, Institute of Metal Physics (Russian Federation)

Published in SPIE Proceedings Vol. 9529:
Optical Methods for Inspection, Characterization, and Imaging of Biomaterials II
Pietro Ferraro; Simonetta Grilli; Monika Ritsch-Marte; David Stifter, Editor(s)

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