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Proceedings Paper

Image reconstruction in cross-sectional optoacoustic tomography based on non-negative constrained model-based inversion
Author(s): Lu Ding; Xose Luís Deán-Ben; Christian Lutzweiler; Daniel Razansky; Vasilis Ntziachristos
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Paper Abstract

In optoacoustic tomography, images representing the light absorption distribution are reconstructed from the measured acoustic pressure waves at several locations around the imaged sample. Most reconstruction algorithms typically yield negative absorption values due to modelling inaccuracies and imperfect measurement conditions. Those negative optical absorption values have no physical meaning and their presence hinders image quantification and interpretation of biological information. We investigate herein the performance of optimization methods that impose non-negative constraints in model-based optoacoustic inversion. Specifically, we analyze the effects of the non-negative restrictions on image quality and accuracy as compared to the unconstrained approach. An efficient algorithm based on the projected quasi-Newton scheme and the limitedmemory Broyden-Fletcher-Goldfarb-Shannon method is used for the non-negative constrained inversion. We showcase that imposing non-negative constraints in model-based reconstruction leads to a quality increase in cross-sectional tomographic optoacoustic images.

Paper Details

Date Published: 16 July 2015
PDF: 6 pages
Proc. SPIE 9539, Opto-Acoustic Methods and Applications in Biophotonics II, 953919 (16 July 2015); doi: 10.1117/12.2183947
Show Author Affiliations
Lu Ding, Institute for Biological and Medical Imaging, Technische Univ. München (Germany)
Xose Luís Deán-Ben, Institute for Biological and Medical Imaging, Technische Univ. München (Germany)
Christian Lutzweiler, Institute for Biological and Medical Imaging, Technische Univ. München (Germany)
Daniel Razansky, Institute for Biological and Medical Imaging, Technische Univ. München (Germany)
Vasilis Ntziachristos, Institute for Biological and Medical Imaging, Technische Univ. München (Germany)


Published in SPIE Proceedings Vol. 9539:
Opto-Acoustic Methods and Applications in Biophotonics II
Vasilis Ntziachristos; Roger Zemp, Editor(s)

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