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Proceedings Paper

Broadband time-resolved diffuse optical spectrometer for clinical diagnostics: characterization and in-vivo measurements in the 600-1350 nm spectral range
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Paper Abstract

We report on the design, performance assessment, and first in vivo measurement of a Time-Resolved Diffuse Optical system for broadband (600-1350 nm) nm measurement of absorption and scattering spectra of biological tissues for non-invasive clinical diagnostics. Two strategies to reduce drift and enhance responsivity are adopted. The system was enrolled in a first in vivo test phase on healthy volunteers, carrying out non-invasive, in vivo quantification of key tissue constituents (oxy- and deoxy-hemoglobin, water, lipids, collagen) and tissue micro-structure (scatterer size and density).

Paper Details

Date Published: 16 July 2015
PDF: 4 pages
Proc. SPIE 9538, Diffuse Optical Imaging V, 95380R (16 July 2015); doi: 10.1117/12.2183835
Show Author Affiliations
Sanathana Konugolu Venkata Sekar, Politecnico di Milano (Italy)
Andrea Farina, Politecnico di Milano (Italy)
Edoardo Martinenghi, Politecnico di Milano (Italy)
Alberto Dalla Mora, Politecnico di Milano (Italy)
Paola Taroni, Politecnico di Milano (Italy)
Antonio Pifferi, Politecnico di Milano (Italy)
Istituto di Fotonica e Nanotechnologie (Italy)
Turgut Durduran, ICFO - Institut de Ciències Fotòniques (Spain)
Marco Pagliazzi, ICFO - Institut de Ciències Fotòniques (Spain)
Claus Lindner, ICFO - Institut de Ciències Fotòniques (Spain)
Parisa Farzam, ICFO - Institut de Ciències Fotòniques (Spain)
Mireia Mora, Institut d'Investigacions Biomédiques August Pi i Sunyer (Spain)
Mattia Squarcia, Ctr. de Dianòstic per la Imatge, Hospital Clínic (Spain)
A. Urbano-Ispizua, Ctr. de Dianòstic per la Imatge, Hospital Clínic (Spain)

Published in SPIE Proceedings Vol. 9538:
Diffuse Optical Imaging V
Hamid Dehghani; Paola Taroni, Editor(s)

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