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Proceedings Paper

Luminescence monitoring of particle delivery into rat skin in vivo
Author(s): E. K. Volkova; I. Yu. Yanina; E. A. Genina; L. E. Dolotov; A. N. Bashkatov; V. D. Genin; J. G. Konyukhova; A. P. Popov; M. D. Kozintseva; E. Speranskaya; M. Lomova; G. S. Terentyuk; A. B. Bucharskaya; N. A. Navolokin; I. Yu. Goryacheva; V. I. Kochubey; D. A. Gorin; V. V. Tuchin; G. B. Sukhorukov
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Paper Abstract

Delivery of upconversion microparticles [Y2O3:Yb, Er] and quantum dots (CuInS2/ZnS coated with PEG-based amphiphilic polymer) into rat skin using the fractional laser microablation has been studied in vivo. Luminescence spectroscopy, optical coherence tomography, confocal microscopy, and histochemical analysis were used for visualization of nanoparticles in microchannels. Results have shown that the upconversion microparticles are detected more efficiently in comparison with the quantum dots. The fluorescence intensity of the inserted upconversion microparticles is higher, when the Omnipaque™ was applied as a skin optical clearing agent. The fluorescent images of upconversion nanoparticle distribution indicate the advantage of particle delivery into skin by ultrasound.

Paper Details

Date Published: 15 July 2015
PDF: 8 pages
Proc. SPIE 9537, Clinical and Biomedical Spectroscopy and Imaging IV, 95371P (15 July 2015); doi: 10.1117/12.2183718
Show Author Affiliations
E. K. Volkova, Saratov State Univ. (Russian Federation)
Univ. of Oulu (Finland)
I. Yu. Yanina, Saratov State Univ. (Russian Federation)
Univ. of Oulu (Finland)
Saratov State Medical Univ. (Russian Federation)
E. A. Genina, Saratov State Univ. (Russian Federation)
L. E. Dolotov, Saratov State Univ. (Russian Federation)
A. N. Bashkatov, Saratov State Univ. (Russian Federation)
V. D. Genin, Saratov State Univ. (Russian Federation)
J. G. Konyukhova, Saratov State Univ. (Russian Federation)
A. P. Popov, Univ. of Oulu (Finland)
M. D. Kozintseva, Saratov State Univ. (Russian Federation)
E. Speranskaya, Saratov State Univ. (Russian Federation)
M. Lomova, Saratov State Univ. (Russian Federation)
G. S. Terentyuk, Saratov State Univ. (Russian Federation)
A. B. Bucharskaya, Saratov State Medical Univ. (Russian Federation)
N. A. Navolokin, Saratov State Medical Univ. (Russian Federation)
I. Yu. Goryacheva, Saratov State Univ. (Russian Federation)
V. I. Kochubey, Saratov State Univ. (Russian Federation)
D. A. Gorin, Saratov State Univ. (Russian Federation)
V. V. Tuchin, Saratov State Univ. (Russian Federation)
Univ. of Oulu (Finland)
Institute of Precise Mechanics and Control RAS (Russian Federation)
G. B. Sukhorukov, Saratov State Univ. (Russian Federation)
Queen Mary Univ. of London (United Kingdom)


Published in SPIE Proceedings Vol. 9537:
Clinical and Biomedical Spectroscopy and Imaging IV
J. Quincy Brown; Volker Deckert, Editor(s)

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