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Proceedings Paper

Combined analysis of whole human blood parameters by Raman spectroscopy and spectral-domain low-coherence interferometry
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Paper Abstract

In this article the simultaneous investigation of blood parameters by complementary optical methods, Raman spectroscopy and spectral-domain low-coherence interferometry, is presented. Thus, the mutual relationship between chemical and physical properties may be investigated, because low-coherence interferometry measures optical properties of the investigated object, while Raman spectroscopy gives information about its molecular composition.

A series of in-vitro measurements were carried out to assess sufficient accuracy for monitoring of blood parameters. A vast number of blood samples with various hematological parameters, collected from different donors, were measured in order to achieve a statistical significance of results and validation of the methods. Preliminary results indicate the benefits in combination of presented complementary methods and form the basis for development of a multimodal system for rapid and accurate optical determination of selected parameters in whole human blood. Future development of optical systems and multivariate calibration models are planned to extend the number of detected blood parameters and provide a robust quantitative multi-component analysis.

Paper Details

Date Published: 15 July 2015
PDF: 5 pages
Proc. SPIE 9537, Clinical and Biomedical Spectroscopy and Imaging IV, 95371N (15 July 2015); doi: 10.1117/12.2183645
Show Author Affiliations
M. Gnyba, Gdańsk Univ. of Technology (Poland)
M. S. Wróbel, Gdańsk Univ. of Technology (Poland)
K. Karpienko, Gdańsk Univ. of Technology (Poland)
D. Milewska, Gdańsk Univ. of Technology (Poland)
M. Jędrzejewska-Szczerska, Gdańsk Univ. of Technology (Poland)


Published in SPIE Proceedings Vol. 9537:
Clinical and Biomedical Spectroscopy and Imaging IV
J. Quincy Brown; Volker Deckert, Editor(s)

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