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Proceedings Paper

Coregistered photoacoustic and ultrasound tomography of healthy and inflamed human interphalangeal joints
Author(s): Peter van Es; Redmar C. Vlieg; Samir K. Biswas; Erwin Hondebrink; Johan C. G. van Hespen; Hein B. J. Moens; Wiendelt Steenbergen; Srirang Manohar
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Paper Abstract

Photoacoustic (PA) or optoacoustic (OA) imaging combines the high (blood) contrast to light with the high-resolution of ultrasound. The method can visualize vascularization deep inside tissue. Of late there is interest in PA imaging of synovial joints which are expected to be associated with increased vascularization in the event of rheumatoid arthritis (RA). We here describe our approach in investigating the application of the PA technique in arthritis. We are developing a CT-geometry version PA finger imager, intended for early clinical assessment of the method. The imager uses two curved array ultrasound detectors each with 64 elements with central frequencies 1.5 and 7.5 MHz respectively, stacked above each other. Both cover approximately 180 degrees of the circle. Illumination is provided with a multiple of optical fiber bundles coupled to a laser-OPO system. Ultrasound imaging is also possible with the system, since the curved arrays are each provided with 12 or 8 ultrasound pulsers. We have investigated systematically imaging of finger vasculature in healthy volunteers using an earlier laboratory prototype. In this paper we present finger imaging results of a patient diagnosed with rheumatoid arthritis.

Paper Details

Date Published: 16 July 2015
PDF: 6 pages
Proc. SPIE 9539, Opto-Acoustic Methods and Applications in Biophotonics II, 95390C (16 July 2015); doi: 10.1117/12.2183633
Show Author Affiliations
Peter van Es, MIRA Institute for Biomedical Technology and Technical Medicine, Univ. of Twente (Netherlands)
Redmar C. Vlieg, MIRA Institute for Biomedical Technology and Technical Medicine, Univ. of Twente (Netherlands)
Samir K. Biswas, MIRA Institute for Biomedical Technology and Technical Medicine, Univ. of Twente (Netherlands)
Erwin Hondebrink, MIRA Institute for Biomedical Technology and Technical Medicine, Univ. of Twente (Netherlands)
Johan C. G. van Hespen, MIRA Institute for Biomedical Technology and Technical Medicine, Univ. of Twente (Netherlands)
Hein B. J. Moens, Ziekenhuis Groep Twente (Netherlands)
Wiendelt Steenbergen, MIRA Institute for Biomedical Technology and Technical Medicine, Univ. of Twente (Netherlands)
Srirang Manohar, MIRA Institute for Biomedical Technology and Technical Medicine, Univ. of Twente (Netherlands)


Published in SPIE Proceedings Vol. 9539:
Opto-Acoustic Methods and Applications in Biophotonics II
Vasilis Ntziachristos; Roger Zemp, Editor(s)

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