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Proceedings Paper

Collagen content as a risk factor in breast cancer? A pilot clinical study
Author(s): Antonio Pifferi; Giovanna Quarto; Francesca Abbate; Nicola Balestreri; Simona Menna; Enrico Cassano; Rinaldo Cubeddu; Paola Taroni
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Paper Abstract

A retrospective pilot clinical study on time domain multi-wavelength (635 to 1060 nm) optical mammography was exploited to assess collagen as a breast-cancer risk factor on a total of 109 subjects (53 healthy and 56 with malignant lesions). An increased cancer occurrence is observed on the 15% subset of patients with higher age-matched collagen content. Further, a similar clustering based on the percentage breast density leads to a different set of patients, possibly indicating collagen as a new independent breast cancer risk factor. If confirmed statistically and on larger numbers, these results could have huge impact on personalized diagnostics, health care systems, as well as on basic research.

Paper Details

Date Published: 16 July 2015
PDF: 4 pages
Proc. SPIE 9538, Diffuse Optical Imaging V, 953813 (16 July 2015); doi: 10.1117/12.2183618
Show Author Affiliations
Antonio Pifferi, Politecnico di Milano (Italy)
Istituto di Fotonica e Nanotecnologie, CNR (Italy)
Giovanna Quarto, Politecnico di Milano (Italy)
Francesca Abbate, European Institute of Oncology (Italy)
Nicola Balestreri, European Institute of Oncology (Italy)
Simona Menna, European Institute of Oncology (Italy)
Enrico Cassano, European Institute of Oncology (Italy)
Rinaldo Cubeddu, Politecnico di Milano (Italy)
Istituto di Fotonica e Nanotecnologie, CNR (Italy)
Paola Taroni, Politecnico di Milano (Italy)

Published in SPIE Proceedings Vol. 9538:
Diffuse Optical Imaging V
Hamid Dehghani; Paola Taroni, Editor(s)

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