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Proceedings Paper

Optical discrimination between malignant and benign breast lesions
Author(s): Giovanna Quarto; Antonio Pifferi; Rinaldo Cubeddu; Francesca Ieva; Anna Maria Paganoni; Francesca Abbate; Enrico Cassano; Paola Taroni
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Paper Abstract

Time domain multi-wavelength (635 to 1060 nm) optical mammography was performed on 82 subjects with breast lesions (45 malignant and 38 benign lesions). A perturbative approach based on the high-order calculation of the pathlength of photons inside the lesion was applied to estimate differences between lesion and average healthy tissue of the same breast in terms of: i) absorption properties, and ii) concentration of the major tissue constituents (oxy- and deoxy-hemoglobin, water, lipid and collagen). The absorption difference Δμa between lesion and healthy tissue is significantly different for malignant vs. benign lesions at all wavelengths. Logistic regression fitted to the absorption data identifies 975 nm as the key wavelength to discriminate malignant from benign lesions. When the difference in tissue composition between lesion and healthy tissue is considered, malignant lesions are characterized by significantly higher collagen content than benign lesions. Also the best model for the discrimination of malignant lesions obtained applying regression logistic to tissue composition is based only on collagen. Including demographic information into the model improves its specificity.

Paper Details

Date Published: 16 July 2015
PDF: 5 pages
Proc. SPIE 9538, Diffuse Optical Imaging V, 953814 (16 July 2015); doi: 10.1117/12.2183616
Show Author Affiliations
Giovanna Quarto, Politecnico di Milano (Italy)
Antonio Pifferi, Politecnico di Milano (Italy)
Istituto di Fotonica e Nanotecnologie, CNR (Italy)
Rinaldo Cubeddu, Politecnico di Milano (Italy)
Istituto di Fotonica e Nanotecnologie, CNR (Italy)
Francesca Ieva, Univ. degli Studi di Milano (Italy)
Anna Maria Paganoni, Politecnico di Milano (Italy)
Francesca Abbate, European Institute of Oncology (Italy)
Enrico Cassano, European Institute of Oncology (Italy)
Paola Taroni, Politecnico di Milano (Italy)

Published in SPIE Proceedings Vol. 9538:
Diffuse Optical Imaging V
Hamid Dehghani; Paola Taroni, Editor(s)

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