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Proceedings Paper

Erythrocyte-derived optical nano-vesicles as theranostic agents
Author(s): Jenny T. Mac; Vicente Nunez; Baharak Bahmani; Yadir Guerrero; Jack Tang; Valentine I. Vullev; Bahman Anvari
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Paper Abstract

We have engineered nano-vesicles, derived from erythrocytes, which can be doped with various near infrared (NIR) organic chromophores, including the FDA-approved indocyanine green (ICG). We refer to these vesicles as NIR erythrocyte-mimicking transducers (NETS) since in response to NIR photo-excitation they can generate heat or emit fluorescent light. Using biochemical methods based on reduction amination, we have functionalized the surface of NET with antibodies to target specific biomolecules. We present results that demonstrate the effectiveness of NETs in targeted imaging of cancer cells that over-express the human epidermal growth factor receptor-2 (HER2).

Paper Details

Date Published: 13 July 2015
PDF: 4 pages
Proc. SPIE 9540, Novel Biophotonics Techniques and Applications III, 95400H (13 July 2015); doi: 10.1117/12.2183587
Show Author Affiliations
Jenny T. Mac, Univ. of California, Riverside (United States)
Vicente Nunez, Univ. of California, Riverside (United States)
Baharak Bahmani, Univ. of California, Riverside (United States)
Yadir Guerrero, Univ. of California, Riverside (United States)
Jack Tang, Univ. of California, Riverside (United States)
Valentine I. Vullev, Univ. of California, Riverside (United States)
Bahman Anvari, Univ. of California, Riverside (United States)


Published in SPIE Proceedings Vol. 9540:
Novel Biophotonics Techniques and Applications III
Arjen Amelink; I. Alex Vitkin, Editor(s)

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