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Proceedings Paper

Gold nanoparticles decorated liposomes and their SERS performance in tumor cells
Author(s): D. Zhu; Z. Y. Wang; S. F. Zong; H. Chen; P. Chen; M. Y. Li; L. Wu; Y. P. Cui
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Paper Abstract

Due to their unique properties, liposomes have been widely used as drug nanocarriers. Herein a liposome-Au nanohybrid has been demonstrated as a SERS active intracellular drug nanocarrier. In this study, cationic Raman reporter tagged gold nanoparticles (Au@4MBA@PAH) were anchored onto the surfaces of anionic liposomes via electrostatic interactions. Using SKBR3 cells as model cells, we revealed that the hybrid formulation can be effectively taken up by tumor cells and tracked by the SERS signals. Collectively, the liposome-Au nanohybrids hold great promise in biomedical applications.

Paper Details

Date Published: 4 May 2015
PDF: 6 pages
Proc. SPIE 9543, Third International Symposium on Laser Interaction with Matter, 954316 (4 May 2015); doi: 10.1117/12.2182146
Show Author Affiliations
D. Zhu, Southeast Univ. (China)
Z. Y. Wang, Southeast Univ. (China)
S. F. Zong, Southeast Univ. (China)
H. Chen, Southeast Univ. (China)
P. Chen, Southeast Univ. (China)
M. Y. Li, Southeast Univ. (China)
L. Wu, Southeast Univ. (China)
Y. P. Cui, Southeast Univ. (China)

Published in SPIE Proceedings Vol. 9543:
Third International Symposium on Laser Interaction with Matter
Yury M. Andreev; Zunqi Lin; Xiaowu Ni; Xisheng Ye, Editor(s)

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