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Proceedings Paper

Non-mydriatic video ophthalmoscope to measure fast temporal changes of the human retina
Author(s): Ralf P. Tornow; Radim Kolář; Jan Odstrčilík
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Paper Abstract

The analysis of fast temporal changes of the human retina can be used to get insight to normal physiological behavior and to detect pathological deviations. This can be important for the early detection of glaucoma and other eye diseases. We developed a small, lightweight, USB powered video ophthalmoscope that allows taking video sequences of the human retina with at least 25 frames per second without dilating the pupil. Short sequences (about 10 s) of the optic nerve head (20° x 15°) are recorded from subjects and registered offline using two-stage process (phase correlation and Lucas-Kanade approach) to compensate for eye movements. From registered video sequences, different parameters can be calculated. Two applications are described here: measurement of (i) cardiac cycle induced pulsatile reflection changes and (ii) eye movements and fixation pattern. Cardiac cycle induced pulsatile reflection changes are caused by changing blood volume in the retina. Waveform and pulse parameters like amplitude and rise time can be measured in any selected areas within the retinal image. Fixation pattern ΔY(ΔX) can be assessed from eye movements during video acquisition. The eye movements ΔX[t], ΔY[t] are derived from image registration results with high temporal (40 ms) and spatial (1,86 arcmin) resolution. Parameters of pulsatile reflection changes and fixation pattern can be affected in beginning glaucoma and the method described here may support early detection of glaucoma and other eye disease.

Paper Details

Date Published: 17 July 2015
PDF: 6 pages
Proc. SPIE 9540, Novel Biophotonics Techniques and Applications III, 954006 (17 July 2015); doi: 10.1117/12.2181183
Show Author Affiliations
Ralf P. Tornow, Friedrich-Alexander-Univ. Erlangen-Nuremberg (Germany)
Radim Kolář, Brno Univ. of Technology (Czech Republic)
St. Anne’s Univ. Hospital Brno (Czech Republic)
Jan Odstrčilík, Brno Univ. of Technology (Czech Republic)
St. Anne’s Univ. Hospital Brno (Czech Republic)


Published in SPIE Proceedings Vol. 9540:
Novel Biophotonics Techniques and Applications III
Arjen Amelink; I. Alex Vitkin, Editor(s)

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