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Proceedings Paper

Optical micro-bubble resonators as promising biosensors
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Paper Abstract

Recently, optical micro-bubble resonators (OMBRs) have gained an increasing interest in many fields of photonics thanks to their particular properties. These hollow microstructures can be suitable for the realization of label – free optical biosensors by combining the whispering gallery mode (WGM) resonator properties with the intrinsic capability of integrated microfluidics. In fact, the WGMs are morphology-dependent modes: any change on the OMBR inner surface (due to chemical and/or biochemical binding) causes a shift of the resonance position and reduces the Q factor value of the cavity. By measuring this shift, it is possible to obtain information on the concentration of the analyte to be detected. A crucial step for the development of an OMBR-based biosensor is constituted by the functionalization of its inner surface. In this work we report on the development of a physical and chemical process able to guarantee a good homogeneity of the deposed bio-layer and, contemporary, to preserve a high quality factor Q of the cavity. The OMBR capability of working as bioassay was proved by different optical techniques, such as the real time measurement of the resonance broadening after each functionalization step and fluorescence microscopy.

Paper Details

Date Published: 5 May 2015
PDF: 7 pages
Proc. SPIE 9506, Optical Sensors 2015, 950617 (5 May 2015); doi: 10.1117/12.2180242
Show Author Affiliations
A. Giannetti, Istituto di Fisica Applicata Nello Carrara, CNR (Italy)
A. Barucci, Istituto di Fisica Applicata Nello Carrara, CNR (Italy)
S. Berneschi, Istituto di Fisica Applicata Nello Carrara, CNR (Italy)
A. Cosci, Ctr. di Studi e Ricerche Enrico Fermi (Italy)
Istituto di Fisica Applicata Nello Carrara, CNR (Italy)
F. Cosi, Istituto di Fisica Applicata Nello Carrara, CNR (Italy)
D. Farnesi, Ctr. di Studi e Ricerche Enrico Fermi (Italy)
Istituto di Fisica Applicata Nello Carrara, CNR (Italy)
G. Nunzi Conti, Istituto di Fisica Applicata Nello Carrara, CNR (Italy)
S. Pelli, Istituto di Fisica Applicata Nello Carrara, CNR (Italy)
Ctr. Studi e Ricerche Enrico Fermi (Italy)
S. Soria, Istituto di Fisica Applicata Nello Carrara, CNR (Italy)
S. Tombelli, Istituto di Fisica Applicata Nello Carrara, CNR (Italy)
C. Trono, Istituto di Fisica Applicata Nello Carrara, CNR (Italy)
G. C. Righini, Ctr. Studi e Ricerche Enrico Fermi (Italy)
Istituto di Fisica Applicata Nello Carrara, CNR (Italy)
F. Baldini, Istituto di Fisica Applicata Nello Carrara, CNR (Italy)


Published in SPIE Proceedings Vol. 9506:
Optical Sensors 2015
Francesco Baldini; Jiri Homola; Robert A. Lieberman, Editor(s)

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