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Proceedings Paper

Preparation and optimization of aminolevulinic acid with gold nanoparticles for photothermal and photodynamic therapies applications
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Paper Abstract

The use of gold nanoparticles (AuNps) as the vehicle for 5-Aminolevulinic acid (ALA) delivery for photodynamic and photothermic plasmonic therapies is a promising approach, especially with the recent demonstration that this photosensitizer immobilization on the particle surface improves reactive oxygen species (ROS) formation, increasing its cytotoxicity. Gold nanorods (AuNRs) present an absorption spectrum shifted to 700 nm, within the tissue transparency window, which allows excitation of the nanoparticles situated deeper in the tissues. Here, we describe a new synthesis method that was applied to control the shape of the gold nanoparticles during its synthesis. To obtain ALA:AuNRs, precursor ALA:AuNps were irradiated by ultrashort laser pulses. The variation of the laser parameters such as pulse energy and duration and irradiation time was assessed. The relevant mechanisms are discussed.

Paper Details

Date Published: 19 June 2015
PDF: 7 pages
Proc. SPIE 9531, Biophotonics South America, 95314C (19 June 2015); doi: 10.1117/12.2180017
Show Author Affiliations
Karina de O. Gonçalves, Univ. Federal de São Paulo (Brazil)
Thiago da Silva Cordeiro, Instituto de Pesquisas Energéticas e Nucleares, CNEN/SP (Brazil)
Flávia de Oliveira Silva, Instituto de Pesquisas Energéticas e Nucleares, CNEN/SP (Brazil)
Ricardo E. Samad, Instituto de Pesquisas Energéticas e Nucleares, CNEN/SP (Brazil)
Nilson D. Vieira Júnior, Instituto de Pesquisas Energéticas e Nucleares, CNEN/SP (Brazil)
Lilia C. Courrol, Univ. Federal de São Paulo (Brazil)
Instituto de Pesquisas Energéticas e Nucleares, CNEN/SP (Brazil)


Published in SPIE Proceedings Vol. 9531:
Biophotonics South America
Cristina Kurachi; Katarina Svanberg; Bruce J. Tromberg; Vanderlei Salvador Bagnato, Editor(s)

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