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Proceedings Paper

Comparison of cerebral microcirculation of alloxan diabetes and healthy mice using laser speckle contrast imaging
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Paper Abstract

The study of blood microcirculation is one of the most important problems of the medicine. This paper presents results of experimental study of cerebral blood flow microcirculation in mice with alloxan-induced diabetes using Temporal Laser Speckle Imaging (TLSI). Additionally, a direct effect of glucose water solution (concentration 20% and 45%) on blood flow microcirculation was studied. In the research, 20 white laboratory mice weighing 20-30 g were used. The TLSI method allows one to investigate time dependent scattering from the objects with complex dynamics, since it possesses greater temporal resolution. Results show that in brain of animal diabetic group diameter of sagittal vein is increased and the speed of blood flow reduced relative to the control group. Topical application of 20%- or 45%-glucose solutions also causes increase of diameter of blood vessels and slows down blood circulation. The results obtained show that diabetes development causes changes in the cerebral microcirculatory system and TLSI techniques can be effectively used to quantify these alterations.

Paper Details

Date Published: 19 March 2015
PDF: 8 pages
Proc. SPIE 9448, Saratov Fall Meeting 2014: Optical Technologies in Biophysics and Medicine XVI; Laser Physics and Photonics XVI; and Computational Biophysics, 94480B (19 March 2015); doi: 10.1117/12.2179988
Show Author Affiliations
Polina A. Timoshina, Saratov State Univ. (Russian Federation)
Britton Chance Ctr. for Biomedical Photonics, Huazhong Univ. of Science and Technology (China)
Rui Shi, Britton Chance Ctr. for Biomedical Photonics, Huazhong Univ. of Science and Technology (China)
Yang Zhang, Britton Chance Ctr. for Biomedical Photonics, Huazhong Univ. of Science and Technology (China)
Dan Zhu, Britton Chance Ctr. for Biomedical Photonics, Huazhong Univ. of Science and Technology (China)
Oxana V. Semyachkina-Glushkovskaya, Saratov State Univ. (Russian Federation)
Britton Chance Ctr. for Biomedical Photonics, Huazhong Univ. of Science and Technology (China)
Valery V. Tuchin, Saratov State Univ. (Russian Federation)
Britton Chance Ctr. for Biomedical Photonics, Huazhong Univ. of Science and Technology (China)
Institute of Precise Mechanics and Control (Russian Federation)
Qingming Luo, Britton Chance Ctr. for Biomedical Photonics, Huazhong Univ. of Science and Technology (China)


Published in SPIE Proceedings Vol. 9448:
Saratov Fall Meeting 2014: Optical Technologies in Biophysics and Medicine XVI; Laser Physics and Photonics XVI; and Computational Biophysics
Elina A. Genina; Vladimir L. Derbov; Kirill V. Larin; Dmitry E. Postnov; Valery V. Tuchin, Editor(s)

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