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Proceedings Paper • Open Access

Bridging molecular and cellular biology with optics (Presentation Video)
Author(s): Gabriel Popescu

Paper Abstract

Understanding the structure and function of living cells from the nano to the micron scale remains a grand challenge. While X-ray diffraction and electron microscopy reveal nanoscale information from cellular structures, they operate with lifeless specimens. By contrast, optical techniques are well suitable for studying live cells. However, the resolution of the far-field “linear” microscopy is approximately 300 nm, a manifestation of Heisenberg’s uncertainty relation. Thus, pushing the biophotonics investigation toward the molecular scale is faced with significant challenges but also with unique opportunities. We will describe various principles dedicated to this goal and present some recent advances in phase sensitive measurements.

Paper Details

Date Published: 27 April 2015
PDF: 1 pages
Proc. SPIE 9339, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications VII, 933902 (27 April 2015); doi: 10.1117/12.2179067
Show Author Affiliations
Gabriel Popescu, Univ. of Illinois at Urbana-Champaign (United States)


Published in SPIE Proceedings Vol. 9339:
Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications VII
Samuel Achilefu; Ramesh Raghavachari, Editor(s)

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