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Proceedings Paper

Fiber optic label-free biophotonic diagnostic tool for cardiovascular disease
Author(s): Cristina Rius; Tobias N. Ackermann; Beatriz Dorado; Xavier Muñoz-Berbel; Vicente Andrés; Andreu Llobera
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Paper Abstract

A label-free compact method for performing photonic characterization of "healthy" versus "diseased" arteries has been developed. It permits the detection of atherosclerotic lesion in living mouse arteries. Using this prototype, we observed that the spectral response (photonic fingerprint, PIN) obtained from aortas of wild-type mice differs from the response of ApoE-KO mice fed with high-fat diet (an atheroprone mouse model). Benchmark of the results against gold standard was performed by staining the aortas with Oil-Red-O to visualize atherosclerotic plaques.

Paper Details

Date Published: 12 June 2015
PDF: 6 pages
Proc. SPIE 9518, Bio-MEMS and Medical Microdevices II, 95180V (12 June 2015); doi: 10.1117/12.2179062
Show Author Affiliations
Cristina Rius, Ctr. Nacional de Investigaciones Cardiovasculares Carlos III (Spain)
Tobias N. Ackermann, Instituto de Microelectrònica de Barcelona, IMB-CNM (CSIC) (Spain)
Beatriz Dorado, Ctr. Nacional de Investigaciones Cardiovasculares Carlos III (Spain)
Xavier Muñoz-Berbel, Instituto de Microelectrònica de Barcelona, IMB-CNM (CSIC) (Spain)
Vicente Andrés, Ctr. Nacional de Investigaciones Cardiovasculares Carlos III (Spain)
Andreu Llobera, Instituto de Microelectrònica de Barcelona, IMB-CNM (CSIC) (Spain)


Published in SPIE Proceedings Vol. 9518:
Bio-MEMS and Medical Microdevices II
Sander van den Driesche, Editor(s)

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