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Proceedings Paper

Biosensing platform combining label-free and labelled analysis using Bloch surface waves
Author(s): Norbert Danz; Alberto Sinibaldi; Peter Munzert; Aleksei Anopchenko; Erik Förster; Stefan Schmieder; Rona Chandrawati; Riccardo Rizzo; Rene Heller; Frank Sonntag; Alessandro Mascioletti; Subinoy Rana; Thomas Schubert; Molly M. Stevens; Francesco Michelotti
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Paper Abstract

Bloch surface waves (BSW) propagating at the boundary of truncated photonic crystals (1D-PC) have emerged as an attractive approach for label-free sensing in plasmon-like sensor configurations. Due to the very low losses in such dielectric thin film stacks, BSW feature very low angular resonance widths compared to the surface plasmon resonance (SPR) case. Besides label-free operation, the large field enhancement and the absence of quenching allow utilizing BSW coupled fluorescence detection to additionally sense the presence of fluorescent labels. This approach can be adapted to the case of angularly resolved resonance detection, thus giving rise to a combined label-free / labelled biosensor platform. It features a parallel analysis of multiple spots arranged as a one-dimensional array inside a microfluidic channel of a disposable chip. Application of such a combined biosensing approach to the detection of the Angiopoietin-2 cancer biomarker in buffer solutions is reported.

Paper Details

Date Published: 5 May 2015
PDF: 8 pages
Proc. SPIE 9506, Optical Sensors 2015, 95060V (5 May 2015); doi: 10.1117/12.2178444
Show Author Affiliations
Norbert Danz, Fraunhofer-Institut für Angewandte Optik und Feinmechanik (Germany)
Alberto Sinibaldi, Univ. degli Studi di Roma La Sapienza (Italy)
Peter Munzert, Fraunhofer-Institut für Angewandte Optik und Feinmechanik (Germany)
Aleksei Anopchenko, Univ. degli Studi di Roma La Sapienza (Italy)
Erik Förster, Fraunhofer-Institut für Angewandte Optik und Feinmechanik (Germany)
Stefan Schmieder, Fraunhofer IWS Dresden (Germany)
Rona Chandrawati, Imperial College London (United Kingdom)
Riccardo Rizzo, Univ. degli Studi di Roma La Sapienza (Italy)
Rene Heller, Radeberger Präzisions- Formen- und Werkzeugbau (Germany)
Frank Sonntag, Fraunhofer IWS Dresden (Germany)
Alessandro Mascioletti, Labor S.r.l. (Italy)
Subinoy Rana, Imperial College London (United Kingdom)
Thomas Schubert, Radeberger Präzisions- Formen- und Werkzeugbau (Germany)
Molly M. Stevens, Imperial College London (United Kingdom)
Francesco Michelotti, Univ. degli Studi di Roma La Sapienza (Italy)


Published in SPIE Proceedings Vol. 9506:
Optical Sensors 2015
Francesco Baldini; Jiri Homola; Robert A. Lieberman, Editor(s)

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