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Proceedings Paper

Freeze-dried polymer-coated quantum dots for perspective biomedical application
Author(s): Valentina V. Goftman; Anna V. Gaynbuch; Elizaveta V. Panfilova; Boris N. Khlebtsov; Irina Yu. Goryacheva
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Paper Abstract

Freeze-drying as known as lyophilization has been considered as a possible technique to improve the long-term stability of colloidal luminescent quantum dots (QDs) for perspective biomedical application. The paper describes synthesis of biocompatible CdSe-based core/shell QDs and discusses their optical and physical properties before and after freezedrying. Importantly, the dried nanoparticles can be stored for a long time under usual conditions and then can easily be redisperse in water at a desired concentration without such hard manipulations as sonication or heating. In this work two PEG-amine derivatives were applied for QDs pegylation: monoamine Jeffamine M1000 and diamine JeffamineED-2003. The use of different Jeffamines allows us to obtain QDs with different length of PEG chains and different ζ-potential. The influence of polymer composition on optical properties of the nanocrystals and on their stability after freeze-drying was studied.

Paper Details

Date Published: 19 March 2015
PDF: 7 pages
Proc. SPIE 9448, Saratov Fall Meeting 2014: Optical Technologies in Biophysics and Medicine XVI; Laser Physics and Photonics XVI; and Computational Biophysics, 94480X (19 March 2015); doi: 10.1117/12.2178368
Show Author Affiliations
Valentina V. Goftman, Saratov State Univ. (Russian Federation)
Ghent Univ. (Belgium)
Anna V. Gaynbuch, Saratov State Univ. (Russian Federation)
Elizaveta V. Panfilova, Institute of Biochemistry and Physiology of Plants and Microorganisms (Russian Federation)
Boris N. Khlebtsov, Institute of Biochemistry and Physiology of Plants and Microorganisms (Russian Federation)
Irina Yu. Goryacheva, Saratov State Univ. (Russian Federation)


Published in SPIE Proceedings Vol. 9448:
Saratov Fall Meeting 2014: Optical Technologies in Biophysics and Medicine XVI; Laser Physics and Photonics XVI; and Computational Biophysics
Elina A. Genina; Vladimir L. Derbov; Kirill V. Larin; Dmitry E. Postnov; Valery V. Tuchin, Editor(s)

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