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Proceedings Paper

Effective compensation for physical effects in 3D single-photon-emission-computed tomography
Author(s): Xiaochuan Pan; Chunwu Wu; Chin-Tu Chen; Chien-Min Kao; John Nathan Aarsvold; Donald Gunter
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Paper Abstract

SPECT can potentially be used for quantitative imaging of in vivo 3D radiopharmaceutical distributions. Attempts for accurate quantitation in 3D SPECT images have been compromise not only by the physical effects of photon attenuation, distance-dependent spatial resolution, and scattering, but also by the lack of effective and efficient methods that will correct for these effects. In this work, we introduce a one-step method that can effectively compensate for the effects of photon attenuation and distance-dependent spatial resolution in 3D SPECT. The correction for these effects requires only a very limited amount of computation in addition to that for 3D reconstruction and hence has the potential for routine clinical application. We use both computer-generated simulations and real data to validate the approach. The results demonstrate that the proposed one-step compensation method results in reconstructed 3D SPECT images with good quantitative information.

Paper Details

Date Published: 18 August 1995
PDF: 7 pages
Proc. SPIE 2622, Optical Engineering Midwest '95, (18 August 1995); doi: 10.1117/12.216874
Show Author Affiliations
Xiaochuan Pan, Univ. of Chicago (United States)
Chunwu Wu, Univ. of Chicago (United States)
Chin-Tu Chen, Univ. of Chicago (United States)
Chien-Min Kao, Univ. of Chicago (United States)
John Nathan Aarsvold, Univ. of Chicago (United States)
Donald Gunter, Univ. of Chicago (United States)

Published in SPIE Proceedings Vol. 2622:
Optical Engineering Midwest '95
Rudolph P. Guzik, Editor(s)

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