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Proceedings Paper

Dosimetry for photodynamic therapy of endometrial tissue
Author(s): Lars Othar Svaasand; Mathias K. Fehr; Sten Madsen; Yona Tadir; Bruce J. Tromberg
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Paper Abstract

Hysterectomy is the most common major operation performed in the United States with dysfunctional uterine bleeding as one of the major indications. The clinical needs for simple and safe endometrial destruction are essential. Photodynamic therapy (PDT) may offer a simple and cost effective solution for the treatment of dysfunctional uterine bleeding. The dosimetry is discussed for the case of topical application of photosensitizer. This technique might be the method of preference because undesired side effects such as skin photosensitization that is typical for systemically injected photosensitizers, can be avoided. Effective PDT requires a sufficient amount of light delivered to the targeted tissue in a reasonable period of time. A trifurcated optical applicator consisting of three cylindrical diffusing fibers has been constructed, and this applicator can deliver a typical required optical dose of about 50-100 J/cm2 to the full depth of the endometrium for an exposure time of 10-20 minutes.

Paper Details

Date Published: 30 May 1995
PDF: 10 pages
Proc. SPIE 2389, Optical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation, (30 May 1995); doi: 10.1117/12.210002
Show Author Affiliations
Lars Othar Svaasand, Beckman Laser Institute and Medical Clinic (United States)
Univ. of Trondheim (Norway)
Mathias K. Fehr, Beckman Laser Institute and Medical Clinic (United States)
Univ. Zuerich (Switzerland)
Sten Madsen, Beckman Laser Institute and Medical Clinic (United States)
Yona Tadir, Beckman Laser Institute and Medical Clinic (United States)
Univ. of California/Irvine (United States)
Bruce J. Tromberg, Beckman Laser Institute and Medical Clinic (United States)


Published in SPIE Proceedings Vol. 2389:
Optical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation
Britton Chance; Robert R. Alfano, Editor(s)

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