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Proceedings Paper

Absolute quantification methods in tissue near-infrared spectroscopy
Author(s): Steven J. Matcher; Peter J. Kirkpatrick; K. Nahid; Mark Cope; David T. Delpy
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Paper Abstract

Recent work aimed at providing an absolute measurement of tissue haemoglobin saturation and a new instrument development, the spatially resolved spectrometer (SRS), are discussed. The theoretical basis of operation of this device and its hardware implementation are described and the results of validation studies on tissue simulating phantoms are presented as are preliminary measurements on human volunteers and observations on patients undergoing neurosurgery. In its present form the instrument appears to produce absolute haemoglobin saturation values for resting human skeletal muscle and the normally perfused human head which are rather low based on physiological expectations. However, we obtained a tight correlation between the saturation values measured by the SRS instrument and those obtained from blood-gas analysis of samples drawn from a jugular bulb catheter in one neurosurgery subject during clamping of the right carotid arteries.

Paper Details

Date Published: 30 May 1995
PDF: 10 pages
Proc. SPIE 2389, Optical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation, (30 May 1995); doi: 10.1117/12.209997
Show Author Affiliations
Steven J. Matcher, Univ. College London (United Kingdom)
Peter J. Kirkpatrick, Addenbrookes Hospital (United Kingdom)
K. Nahid, Univ. College London (United Kingdom)
Mark Cope, Univ. College London (United Kingdom)
David T. Delpy, Univ. College London (United Kingdom)


Published in SPIE Proceedings Vol. 2389:
Optical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation
Britton Chance; Robert R. Alfano, Editor(s)

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