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Proceedings Paper

Forward and inverse calculations for 3D frequency-domain diffuse optical tomography
Author(s): Brian W. Pogue; Michael S. Patterson; Thomas J. Farrell
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Paper Abstract

A fast iterative imaging algorithm has been developed to examine the potential of diffuse optical tomography (DOT) for clinical imaging. Forward calculations using diffusion theory were used to generate light fluence distributions within highly scattering media such as tissue. A 3D multigrid finite difference algorithm has been employed to solve the complex diffusion equation in the frequency-domain for irregular objects with spatially varying absorption and scattering coefficients. An iteractive inversion scheme has been used to solve for the distribution of interaction coefficients from tomographic measurements of the phase and amplitude of the AC photon density at the surface of the object. The time required to calculate images can be minimized using the multigrid finite difference forward solution along with a Newton-Raphson steepest descent inversion algorithm. The potential of DOT was evaluated using theoretical 3D test objects with various absorption and scattering inhomogeneities from which the phase and amplitude data were calculated from both finite difference and Monte Carlo simulations. Estimates of the resolution and contrast were calculated in order to assess the detectability of biological targets, such as tumors, blood volume changes, or blood oxygenation changes. The 3D nature of these calculations should be beneficial for optimized iterative reconstruction.

Paper Details

Date Published: 30 May 1995
PDF: 12 pages
Proc. SPIE 2389, Optical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation, (30 May 1995); doi: 10.1117/12.209983
Show Author Affiliations
Brian W. Pogue, Hamilton Regional Cancer Ctr. and McMaster Univ. (United States)
Michael S. Patterson, Hamilton Regional Cancer Ctr., McMaster Univ., and Univ. of Toronto (Canada)
Thomas J. Farrell, Hamilton Regional Cancer Ctr. (Canada)

Published in SPIE Proceedings Vol. 2389:
Optical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation
Britton Chance; Robert R. Alfano, Editor(s)

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