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Proceedings Paper

Monte Carlo investigations of elastic scattering spectroscopy applied to latex spheres used as tissue phantoms
Author(s): James D. Boyer; Judith R. Mourant; Irving J. Bigio
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Paper Abstract

An optical-fiber-coupled, elastic-scatter spectrometer has proven effective in discriminating between malignant and nonmalignant tissue in the human bladder and gastrointestinal tract. The system injects broadband light into the tissue with an optical fiber and spectrally analyzes the returning light collected by an adjacent fiber. The collected photons have experienced multiple scattering events and therefore arrive at the analysis fiber after traveling varied paths. The diameter of the source fiber is comparable to its separation from the collection fiber. The diffusion model is inappropriate for this geometry; therefore, Monte Carlo simulations are used. In addition, the size of the scattering sites in tissue are expected to be of the same order as the excitation wavelengths, and Mie theory is expected to provide the best description of the scattering and extinction. We will present and compare the results of simulations and measurements of the elastic scatter signal for suspensions of latex spheres in hemoglobin solutions of varying concentrations.

Paper Details

Date Published: 30 May 1995
PDF: 10 pages
Proc. SPIE 2389, Optical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation, (30 May 1995); doi: 10.1117/12.209958
Show Author Affiliations
James D. Boyer, Los Alamos National Lab. (United States)
Judith R. Mourant, Los Alamos National Lab. (United States)
Irving J. Bigio, Los Alamos National Lab. (United States)


Published in SPIE Proceedings Vol. 2389:
Optical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation
Britton Chance; Robert R. Alfano, Editor(s)

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