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Proceedings Paper

Effect of low-power laser on wound healing at the site of tracheal anastomosis in rats
Author(s): Koji Sensaki; Tsunenori Arai; Susumu Tanaka; Makoto Kikuchi
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Paper Abstract

The effect of low power laser on the wound healing process was investigated at the site of anastomosis in rats. Tracheal reconstruction was performed after the tracheal transection and He-Ne laser (NEC,GLG5360, wavelength 632.8 nm)(3.3 X 10-3 W/cm2, 5 min) was irradiated to the site of anastomosis. Structural and functional recoveries were evaluated at 1 and 2 weeks postoperatively. Hydroxyproline content, epithelial condition, cellular infiltration, fiber proliferation, microstructure of cilia, mucociliary function and neovascularization were measured. Hydroxyproline was measured with Amino acid autoanalyzer (Hitachi 835-50). Microstructure of cilia was observed with scanning electron microscope (JSN-840, JEOL). Mucociliary function was evaluated by India ink movement. The hydroxyproline contents per 1 mg dry weight in irradiated group and control group were equivalent (approximately 20 (mu) g). Cellular infiltration of irradiated group was fewer than that of control group. The degree of mucociliary functional recovery in the irradiated group was better than that of control group. Among the cases that showed the structural recovery of cilia, the functional recovery was observed in whole irradiated group, and in 40% of control group. Neovascularization was more pronounced in irradiated group. From this study it is suggested that the laser irradiation may reduce the inflammation and promote the recovery of mucociliary function at the site of anastomosis.

Paper Details

Date Published: 22 May 1995
PDF: 7 pages
Proc. SPIE 2391, Laser-Tissue Interaction VI, (22 May 1995); doi: 10.1117/12.209931
Show Author Affiliations
Koji Sensaki, National Defense Medical College (Japan)
Tsunenori Arai, National Defense Medical College (Japan)
Susumu Tanaka, National Defense Medical College (Japan)
Makoto Kikuchi, National Defense Medical College (Japan)

Published in SPIE Proceedings Vol. 2391:
Laser-Tissue Interaction VI
Steven L. Jacques, Editor(s)

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