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Proceedings Paper

Comparison of photobleaching and fluence rate effects in PpIX and BPD-MA photosensitization of rat bladder tumor in vivo
Author(s): Seiichi Iinuma; Georges A. Wagnieres; Kevin T. Schomacker; Mike Bamberg; Tayyaba Hasan
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Paper Abstract

Photobleaching of 5-aminolevulinic acid (ALA) -induced protoporphyrin IX (PpIX) and benzoporphyrin derivative-monoacid ring A (BPD-MA) was investigated using an orthotopic rat bladder tumor model. For both photosensitizers used, the photobleaching rate constant was not fluence- rate-dependent under conditions that photodynamic response was fluence rate-dependent. These data suggest that photobleaching pathways may be independent of the photochemical paths involved in tissue destruction. The fluorescence spectrum was followed during irradiation by using laser-induced fluorescence method and a build-up of photoproducts of PpIX was observed whereas no fluorescence of photoproducts was obtained in the case of BPD-MA.

Paper Details

Date Published: 22 May 1995
PDF: 7 pages
Proc. SPIE 2391, Laser-Tissue Interaction VI, (22 May 1995); doi: 10.1117/12.209886
Show Author Affiliations
Seiichi Iinuma, Keio Univ. (Japan)
Georges A. Wagnieres, Ecole Polytechnique Federale de Lausanne (Switzerland)
Kevin T. Schomacker, Wellman Labs. of Photomedicine, Massachusetts General Hospital, and Harvard Medical School (United States)
Mike Bamberg, Wellman Labs. of Photomedicine, Massachusetts General Hospital, and Harvard Medical School (United States)
Tayyaba Hasan, Wellman Labs. of Photomedicine, Massachusetts General Hospital, and Harvard Medical School (United States)


Published in SPIE Proceedings Vol. 2391:
Laser-Tissue Interaction VI
Steven L. Jacques, Editor(s)

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