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Proceedings Paper

Laser-induced stress transients: applications for molecular delivery
Author(s): Thomas J. Flotte; Shun Lee; Hong Zhang; Daniel J. McAuliffe; Tina Douki; Apostolos George Doukas
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Paper Abstract

Lasers can be used to enhance the delivery of a number of molecules. Other investigators have demonstrated local release of molecules from liposomes following laser irradiation, microbeam disruption of the cell membrane to increase cell transport, microbeam ablation of the zona pellucida surrounding the ovum to increase the chances of fertilization, and increased transcutaneous transport following ablation of the stratum corneum. Our experiments have shown that laser-induced stress transients can be utilized as a vector for intracellular delivery of molecules that may or may not normally cross the cell membrane. These two conditions have been tested with Photofrin and DNA. This technology may have applications in cell and molecular biology, cancer therapy, gene therapy, and others.

Paper Details

Date Published: 22 May 1995
PDF: 6 pages
Proc. SPIE 2391, Laser-Tissue Interaction VI, (22 May 1995); doi: 10.1117/12.209883
Show Author Affiliations
Thomas J. Flotte, Wellman Labs. of Photomedicine, Massachusetts General Hospital, and Harvard Medical School (United States)
Shun Lee, Wellman Labs. of Photomedicine, Massachusetts General Hospital, and Harvard Medical School (United States)
Hong Zhang, Wellman Labs. of Photomedicine, Massachusetts General Hospital, and Harvard Medical School (United States)
Daniel J. McAuliffe, Wellman Labs. of Photomedicine, Massachusetts General Hospital, and Harvard Medical School (United States)
Tina Douki, Wellman Labs. of Photomedicine, Massachusetts General Hospital, and Harvard Medical School (United States)
Apostolos George Doukas, Wellman Labs. of Photomedicine, Massachusetts General Hospital, and Harvard Medical School (United States)


Published in SPIE Proceedings Vol. 2391:
Laser-Tissue Interaction VI
Steven L. Jacques, Editor(s)

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