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Proceedings Paper

Measuring ocular characteristics after gel injection adjustable keratoplasty (GIAK) in the rabbit
Author(s): Jason I. Comander; Jean-Marie A. Parel; Gabriel Simon; Yoshiko Takesue; Franck L. Villain
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Paper Abstract

Gel Injection Adjustable Keratoplasty (GIAK) is a refractive surgery procedure which uses an ocular ring implant made of a polyethylene oxide hydrogel to cause a refractive change in the cornea. Unlike laser photo refractive keratectomy, GIAK does not interfere with the central cornea because the ring lies around the optical axis. Thus, vision can be assessed immediately after surgery. Our in vivo study was designed to quantify GIAK's effects on tissues, the biocompatibility of the polymer and in the process investigate which ocular changes in the rabbit model can be monitored with precision using current technology. Thirty-two young rabbits underwent a delamination in one eye, 22 of which were injected with a new polymeric gel. Corneal topography, keratometry, pachymetry, and tonometry were performed on both eyes for up to 105 days. All corneas flattened with growth. In GIAK animals, we found an average flattening of 6.51 +/- 1.23 diopters (p < 0.0001) relative to the fellow eye. No statistically significant regression over the 102 days was observed. Intraocular pressure dropped slightly by 0.69 +/- 1.21 mmHg (p equals 0.025), a clinically insignificant value, while no significant change was detected in corneal thickness. Keratometry can be tracked in rabbits after GIAK surgery from POD 1. Measuring unoperated fellow eyes allows for the effects of surgery to be assessed without bias from growth. Using this protocol, GIAK was shown to be stable. It was more difficult to draw conclusions from pachymetry, tonometry, and topography data.

Paper Details

Date Published: 22 May 1995
PDF: 7 pages
Proc. SPIE 2393, Ophthalmic Technologies V, (22 May 1995); doi: 10.1117/12.209828
Show Author Affiliations
Jason I. Comander, Bascom Palmer Eye Institute/Univ. of Miami School of Medicine (United States)
Harvard Univ. (United States)
Jean-Marie A. Parel, Bascom Palmer Eye Institute/Univ. of Miami School of Medicine (United States)
Univ. de Paris Hopital de l'Hotel-Dieu (France)
Gabriel Simon, Bascom Palmer Eye Institute/Univ. of Miami School of Medicine (United States)
Yoshiko Takesue, Bascom Palmer Eye Institute/Univ. of Miami School of Medicine (United States)
Fukuoka Univ. (Japan)
Franck L. Villain, Bascom Palmer Eye Institute/Univ. of Miami School of Medicine (United States)


Published in SPIE Proceedings Vol. 2393:
Ophthalmic Technologies V
Jean-Marie Parel; Qiushi Ren; Karen Margaret Joos, Editor(s)

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