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Proceedings Paper

Segmentation and analysis of DNA replication sites using deformable models
Author(s): Raghu P. Menon; Raj S. Acharya; Jagath K. Samarabandu; Ping Chin Cheng; Ronald Berezney
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Paper Abstract

Image segmentation is an important aspect of biomedical image analysis. Here we discuss the implementation of a system for segmentation of confocal electron microscope images of DNA within from rat liver cell nuclei. Segmentation is achieved using controlled continuity splines or 'snakes' proposed by Kass, Witkin, and Teraopoulos. A snake is an energy minimizing spline guided by external constraint forces and influenced by image forces that pull it toward features such as lines and edges. They are active contour models. They lock onto nearby edges, localizing them accurately.

Paper Details

Date Published: 24 May 1995
PDF: 7 pages
Proc. SPIE 2433, Medical Imaging 1995: Physiology and Function from Multidimensional Images, (24 May 1995); doi: 10.1117/12.209717
Show Author Affiliations
Raghu P. Menon, SUNY/Buffalo (United States)
Raj S. Acharya, SUNY/Buffalo (United States)
Jagath K. Samarabandu, SUNY/Buffalo (United States)
Ping Chin Cheng, SUNY/Buffalo (United States)
Ronald Berezney, SUNY/Buffalo (United States)


Published in SPIE Proceedings Vol. 2433:
Medical Imaging 1995: Physiology and Function from Multidimensional Images
Eric A. Hoffman, Editor(s)

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