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Proceedings Paper

Comparison of kinetic models for data from a positron emission tomograph
Author(s): Pamela G. Coxson; Ronald H. Huesman; Sophanie Lim; Gregory J. Klein; Bryan W. Reutter; Thomas F. Budinger
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Paper Abstract

The purpose of this research was to compare a physiological model of 82Rb in the myocardium with two reduced order models with regard to their ability to assess physiological parameters of diagnostic significance. A three compartment physiological model of 82Rb uptake in the myocardium was used to simulate kinetic region of interest data from a positron emission tomograph (PET). Simulations were generated for eight different blood flow rates reflecting the physiological range of interest. Two reduced order models which are commonly used with myocardial PET studies were fit to the simulated data and the parameters of the reduced order models were compared with the physiological parameters. Then all three models were fit to the simulated data with noise added. Monte carlo simulations were used to evaluate and compare the diagnostic utility of the reduced order models.

Paper Details

Date Published: 24 May 1995
PDF: 11 pages
Proc. SPIE 2433, Medical Imaging 1995: Physiology and Function from Multidimensional Images, (24 May 1995); doi: 10.1117/12.209695
Show Author Affiliations
Pamela G. Coxson, Lawrence Berkeley Lab. (United States)
Ronald H. Huesman, Lawrence Berkeley Lab. (United States)
Sophanie Lim, Lawrence Berkeley Lab. (United States)
Gregory J. Klein, Lawrence Berkeley Lab. (United States)
Bryan W. Reutter, Lawrence Berkeley Lab. (United States)
Thomas F. Budinger, Lawrence Berkeley Lab. (United States)


Published in SPIE Proceedings Vol. 2433:
Medical Imaging 1995: Physiology and Function from Multidimensional Images
Eric A. Hoffman, Editor(s)

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