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Proceedings Paper

Optical properties of normal and malignant tissues in the nasopharynx and larynx
Author(s): Calum E. MacAulay; Stephen Lam; Jianan Y. Qu; C. Man; M. Harries; Branko Palcic
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Paper Abstract

Differences in tissue autofluorescence between normal bronchial tissue and cancerous or pre cancerous bronchial tissue have been documented and exploited for the early detection of lung cancer (1,2) The larynx and nasopharynx have not been so well studied. Even with the most advanced fiber-optic equipment in experienced hands, the nasopharynx is an accessible but challenging area to examine. Small nasopharyngeal carcinoma are difficult to detect. For the larynx the challenge is the precise tumour localization which will allow more accurate staging of the malignant disease. The thought is that the tissue autofluorescence and tissue optical properties (absorption and scattering) which allow one to detect and localize early lesions in the bronchial tree may be similar in the larynx and nasopharynx and likewise exploitable for detection and delineation of lesions. The major characteristics of the autofluorescence properties of bronchial tissue, which may be found to be similar in other sites, are summarized below.

Paper Details

Date Published: 12 May 1995
PDF: 5 pages
Proc. SPIE 2395, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems V, (12 May 1995); doi: 10.1117/12.209097
Show Author Affiliations
Calum E. MacAulay, British Columbia Cancer Agency (Canada)
Stephen Lam, British Columbia Cancer Agency (Canada)
Jianan Y. Qu, British Columbia Cancer Agency (Canada)
C. Man, Univ. of British Columbia (Canada)
M. Harries, The Royal National Throat, Nose & Ear Hospital (United Kingdom)
Branko Palcic, British Columbia Cancer Agency (Canada)

Published in SPIE Proceedings Vol. 2395:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems V
R. Rox Anderson; Graham M. Watson; Rudolf W. Steiner; Douglas E. Johnson; Stanley M. Shapshay; Michail M. Pankratov; George S. Abela; Lawrence S. Bass; John V. White; Rodney A. White; Kenneth Eugene Bartels; Lloyd P. Tate; C. Thomas Vangsness, Editor(s)

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