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Proceedings Paper

Comparison of the extent of Nd:YAG and diode (810 nm) laser-induced thermal coagulation of human prostate: a histopathological analysis of acute response
Author(s): Eduardo Orihuela; Mariela Pow-Sang; Steve Johnson; Daniel Cowan; Michael M. Warren; Massoud Motamedi
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Paper Abstract

The objective of the study was to compare the extent of thermocoagulation induced in the human prostate by two regimens of Nd:YAG laser (50 W X 60 s and 15 W X 180 s) and one regimen of diode (810 nm) laser (15 W X 180 s). Powers were measured at the fiber tip. The study was conducted in 6 patients undergoing radical prostatectomy because of malignancy whose prostates were treated transurethrally with laser radiation at the time of the procedure. The prostate specimens were retrieved approximately 90 minutes after laser treatment, and then prepared for histological examination. In all the cases, the diode laser was applied to the left side of the prostate and the Nd:YAG laser (either regimen) to the right side, in order to prevent treatment variables related to histological composition. Coagulation necrosis was confined within the transition zone in all the case and at times BPH was unaffected, if nodular. Similar depth of coagulation was observed for both Nd:YAG regimens (mean 12 mm, range 10 to 14) and the depth of coagulation was slightly less for the diode laser (mean 10.6 mm, range 8 to 14). Our results suggest that, at the studied dosimetries, the thermocoagulation effect of diode laser in the human prostate approximates to that seen with Nd:YAG laser.

Paper Details

Date Published: 12 May 1995
PDF: 8 pages
Proc. SPIE 2395, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems V, (12 May 1995); doi: 10.1117/12.209083
Show Author Affiliations
Eduardo Orihuela, Univ. of Texas Medical Branch at Galveston (United States)
Mariela Pow-Sang, Univ. of Texas Medical Branch at Galveston (United States)
Steve Johnson, Univ. of Texas Medical Branch at Galveston (United States)
Daniel Cowan, Univ. of Texas Medical Branch at Galveston (United States)
Michael M. Warren, Univ. of Texas Medical Branch at Galveston (United States)
Massoud Motamedi, Univ. of Texas Medical Branch at Galveston (United States)


Published in SPIE Proceedings Vol. 2395:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems V
R. Rox Anderson; Graham M. Watson; Rudolf W. Steiner; Douglas E. Johnson; Stanley M. Shapshay; Michail M. Pankratov; George S. Abela; Lawrence S. Bass; John V. White; Rodney A. White; Kenneth Eugene Bartels; Lloyd P. Tate; C. Thomas Vangsness, Editor(s)

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