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Proceedings Paper

New noninvasive imaging technique for cataract evaluation in the rhesus monkey
Author(s): Cheryl Dawn DiCarlo; Stephen A. Boppart; Donald A. Gagliano; Rodney E. Amnotte; Audrey B. Smith; Daniel X. Hammer; Ann B. Cox; Michael R. Hee; James G. Fujimoto; Eric A. Swanson; William P. Roach
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Paper Abstract

We present the first in vivo study using Optical Coherence Tomography (OCT) as the imaging device for lenticular cataracts in the geriatric rhesus monkey. OCT is a non-invasive imaging technique that produces a 2D cross sectional image of intraocular tissue similar to ultrasound B scan. In OCT the images are formed by measuring optical reflections from the tissue. Eighteen geriatric subjects with documented lenticular opacities and one control subject were imaged. The OCT images produced are compared to current and previous clinical cataract grading exams and slit-lamp photography. Histopathology was collected on one subject and is compared to the OCT image. OCT provides information on nuclear, cortical and subcapsular opacities. The image formation is presented based on a color coded computer generated log reflective scale. The log reflective scale is converted to a qualitative grading system. Although movement and shadow artifact can occur, these are readily identifiable and can be differentiated from underlying lenticular abnormalities. OCT has great potential to assist in further characterization of cataracts.

Paper Details

Date Published: 12 May 1995
PDF: 8 pages
Proc. SPIE 2395, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems V, (12 May 1995); doi: 10.1117/12.209062
Show Author Affiliations
Cheryl Dawn DiCarlo, Air Force Armstrong Lab. (United States)
Stephen A. Boppart, Massachusetts Institute of Technology (United States)
Donald A. Gagliano, U.S. Army Medical Research Detachment (United States)
Rodney E. Amnotte, Air Force Armstrong Lab. (United States)
Audrey B. Smith, The Analytical Sciences Corp. (United States)
Daniel X. Hammer, Air Force Armstrong Lab. (United States)
Ann B. Cox, Air Force Armstrong Lab. (United States)
Michael R. Hee, Massachusetts Institute of Technology (United States)
James G. Fujimoto, Massachusetts Institute of Technology (United States)
Eric A. Swanson, MIT Lincoln Lab. (United States)
William P. Roach, Air Force Armstrong Lab. (United States)


Published in SPIE Proceedings Vol. 2395:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems V
R. Rox Anderson; Graham M. Watson; Rudolf W. Steiner; Douglas E. Johnson; Stanley M. Shapshay; Michail M. Pankratov; George S. Abela; Lawrence S. Bass; John V. White; Rodney A. White; Kenneth Eugene Bartels; Lloyd P. Tate; C. Thomas Vangsness, Editor(s)

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