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Proceedings Paper

Nature-inspired magnetoelastic biosentinels for the detection of pathogenic bacteria in stagnant liquids
Author(s): Shin Horikawa; Yating Chai; Howard C. Wikle; Jing Dai; Jiajia Hu; Sang-Jin Suh; Vitaly Vodyanoy; Bryan A. Chin
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Paper Abstract

This paper presents an investigation into magnetoelastic (ME) biosentinels that capture and detect low-concentration pathogenic bacteria in stagnant liquids. The ME biosentinels are designed to mimic a variety of white blood cell types, known as the main defensive mechanism in the human body against different pathogenic invaders. The ME biosentinels are composed of a freestanding ME resonator coated with an engineered phage that specifically binds with the pathogens of interest. These biosentinels are ferromagnetic and thus can be moved through a liquid by externally applied magnetic fields. In addition, when a time-varying magnetic field is applied, the ME biosentinels can be placed into mechanical resonance by magnetostriction. As soon as the biosentinels bind with the target pathogen through the phage-based biomolecular recognition, a change in the biosentinel’s resonant frequency occurs, and thereby the presence of the target pathogen can be detected. Detection of Bacillus anthracis spores under stagnant flow conditions was demonstrated.

Paper Details

Date Published: 13 May 2015
PDF: 8 pages
Proc. SPIE 9488, Sensing for Agriculture and Food Quality and Safety VII, 94880C (13 May 2015); doi: 10.1117/12.2087766
Show Author Affiliations
Shin Horikawa, Auburn Univ. (United States)
Yating Chai, Auburn Univ. (United States)
Howard C. Wikle, Auburn Univ. (United States)
Jing Dai, Auburn Univ. (United States)
Jiajia Hu, Changzhou Univ. (China)
Sang-Jin Suh, Auburn Univ. (United States)
Vitaly Vodyanoy, Auburn Univ. (United States)
Bryan A. Chin, Auburn Univ. (United States)


Published in SPIE Proceedings Vol. 9488:
Sensing for Agriculture and Food Quality and Safety VII
Moon S. Kim; Kuanglin Chao; Bryan A. Chin, Editor(s)

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