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Proceedings Paper

Fabricating optical phantoms to simulate skin tissue properties and microvasculatures
Author(s): Shuwei Sheng; Qiang Wu; Yilin Han; Erbao Dong; Ronald Xu
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Paper Abstract

This paper introduces novel methods to fabricate optical phantoms that simulate the morphologic, optical, and microvascular characteristics of skin tissue. The multi-layer skin-simulating phantom was fabricated by a light-cured 3D printer that mixed and printed the colorless light-curable ink with the absorption and the scattering ingredients for the designated optical properties. The simulated microvascular network was fabricated by a soft lithography process to embed microchannels in polydimethylsiloxane (PDMS) phantoms. The phantoms also simulated vascular anomalies and hypoxia commonly observed in cancer. A dual-modal multispectral and laser speckle imaging system was used for oxygen and perfusion imaging of the tissue-simulating phantoms. The light-cured 3D printing technique and the soft lithography process may enable freeform fabrication of skin-simulating phantoms that embed microvessels for image and drug delivery applications.

Paper Details

Date Published: 6 March 2015
PDF: 13 pages
Proc. SPIE 9325, Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue VII, 932507 (6 March 2015); doi: 10.1117/12.2086470
Show Author Affiliations
Shuwei Sheng, Univ. of Science and Technology of China (China)
Qiang Wu, Univ. of Science and Technology of China (China)
Yilin Han, Univ. of Science and Technology of China (China)
Erbao Dong, Univ. of Science and Technology of China (China)
Ronald Xu, Univ. of Science and Technology of China (United States)
The Ohio State Univ. (China)


Published in SPIE Proceedings Vol. 9325:
Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue VII
David W. Allen; Jean-Pierre Bouchard, Editor(s)

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