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Proceedings Paper

Probe-pin device for optical neurotransmitter sensing in the brain
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Paper Abstract

Development of an optical neurotransmitter sensing device using nano-plasmonic probes and a micro-spectrometer for real time monitoring of neural signals in the brain is underway. Clinical application of this device technology is to provide autonomous closed-loop feedback control to a deep brain stimulation (DBS) system and enhance the accuracy and efficacy of DBS treatment. By far, we have developed an implantable probe-pin device based on localized field enhancement of surface plasmonic resonance on a nanostructured sensing domain which can amplify neurochemical signals from evoked neural activity in the brain. In this paper, we will introduce the details of design and sensing performance of a proto-typed microspectrometer and nanostructured probing devices for real time measurement of neurotransmitter concentrations.

Paper Details

Date Published: 3 April 2015
PDF: 6 pages
Proc. SPIE 9434, Nanosensors, Biosensors, and Info-Tech Sensors and Systems 2015, 943409 (3 April 2015); doi: 10.1117/12.2085610
Show Author Affiliations
Min Hyuck Kim, Norfolk State Univ. (United States)
Kyo D. Song, Norfolk State Univ. (United States)
Hargsoon Yoon, Norfolk State Univ. (United States)
Yeonjoon Park, NASA Langley Research Ctr. (United States)
Sang H. Choi, NASA Langley Research Ctr. (United States)
Dae-Sung Lee, Korea Electronics Technology Institute (Korea, Republic of)
Kyu-Sik Shin, Korea Electronics Technology Institute (Korea, Republic of)
Hak-In Hwang, Korea Electronics Technology Institute (Korea, Republic of)
Uhn Lee, Gachon Univ. (Korea, Republic of)


Published in SPIE Proceedings Vol. 9434:
Nanosensors, Biosensors, and Info-Tech Sensors and Systems 2015
Vijay K. Varadan, Editor(s)

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