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Proceedings Paper

Real-time quantitative fluorescence imaging using a single snapshot optical properties technique for neurosurgical guidance
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Paper Abstract

Fluorescence imaging has shown promise as an adjunct to improve the extent of resection in neurosurgery and oncologic surgery. Nevertheless, current fluorescence imaging techniques do not account for the heterogeneous attenuation effects of tissue optical properties. In this work, we present a novel imaging system that performs real time quantitative fluorescence imaging using Single Snapshot Optical Properties (SSOP) imaging. We developed the technique and performed initial phantom studies to validate the quantitative capabilities of the system for intraoperative feasibility. Overall, this work introduces a novel real-time quantitative fluorescence imaging method capable of being used intraoperatively for neurosurgical guidance.

Paper Details

Date Published: 10 March 2015
PDF: 6 pages
Proc. SPIE 9305, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics II, 93050J (10 March 2015); doi: 10.1117/12.2085051
Show Author Affiliations
Pablo A. Valdes, Harvard Medical School (United States)
Brigham and Women's Hospital (United States)
Joseph Angelo, Beth Israel Deaconess Medical Ctr. (United States)
Sylvain Gioux, Harvard Medical School (United States)
Brigham and Women's Hospital (United States)


Published in SPIE Proceedings Vol. 9305:
Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics II
Henry Hirschberg; E. Duco Jansen; Samarendra K. Mohanty; Nitish V. Thakor; Qingming Luo; Steen J. Madsen, Editor(s)

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