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Proceedings Paper

Real-time interleaved photoacoustic/ultrasound (PAUS) imaging for interventional procedure guidance
Author(s): Chen-wei Wei; Thu-Mai Nguyen; Jinjun Xia; Bastien Arnal; Ivan Pelivanov; Matthew O’Donnell
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Paper Abstract

Ultrasound-guided photoacoustic imaging has shown great potential for many clinical applications including vascular visualization, detection of nanoprobes sensing molecular profiles, and guidance of interventional procedures. However, bulky and costly lasers are usually required to provide sufficient pulse energies for deep imaging. The low pulse repetition rate also limits potential real-time applications of integrated photoacoustic/ultrasound (PAUS) imaging. With a compact and low-cost laser operating at a kHz repetition rate, we aim to integrate photoacoustics (PA) into a commercial ultrasound (US) machine utilizing an interleaved scanning approach for clinical translation, with imaging depth up to a few centimeters and frame rates > 30 Hz. Multiple PA sub-frames are formed by scanning laser firings covering a large scan region with a rotating galvo mirror, and then combined into a final frame. Ultrasound pulse-echo beams are interleaved between laser firings/PA receives. The approach was implemented with a diode-pumped laser, a commercial US scanner, and a linear array transducer. Insertion of an 18-gauge needle into a piece of chicken tissue, with subsequent injection of an absorptive agent into the tissue, was imaged with an integrated PAUS frame rate of 30 Hz, covering a 2.8 cm × 2.8 cm imaging plane. Given this real-time image rate and high contrast (> 40 dB at more than 1-cm depth in the PA image), we have demonstrated that this approach is potentially attractive for clinical procedure guidance.

Paper Details

Date Published: 11 March 2015
PDF: 4 pages
Proc. SPIE 9323, Photons Plus Ultrasound: Imaging and Sensing 2015, 93233J (11 March 2015); doi: 10.1117/12.2084704
Show Author Affiliations
Chen-wei Wei, Univ. of Washington (United States)
Thu-Mai Nguyen, Univ. of Washington (United States)
Jinjun Xia, Univ. of Washington (United States)
Bastien Arnal, Univ. of Washington (United States)
Ivan Pelivanov, Univ. of Washington (United States)
International Laser Ctr. (Russian Federation)
Matthew O’Donnell, Univ. of Washington (United States)


Published in SPIE Proceedings Vol. 9323:
Photons Plus Ultrasound: Imaging and Sensing 2015
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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