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Proceedings Paper

Towards secondary use of heterogeneous radio-oncological data for retrospective clinical trials: service-oriented connection of a central research database with image analysis tools
Author(s): Nina Bougatf; Rolf Bendl; Jürgen Debus
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Paper Abstract

Our overall objective is the utilization of heterogeneous and distributed radio-oncological data in retrospective clinical trials. Previously, we have successfully introduced a central research database for collection of heterogeneous data from distributed systems. The next step is the integration of image analysis tools in the standard retrieval process. Hence, analyses for complex medical questions can be processed automatically and facilitated immensely. In radiation oncology recurrence analysis is a central approach for the evaluation of therapeutic concepts. However, various analysis steps have to be performed like image registration, dose transformation and dose statistics.

In this paper we show the integration of image analysis tools in the standard retrieval process by connecting them with our central research database using a service-oriented approach. A concrete problem from recurrence analysis has been selected to prove our concept exemplarily. We implemented service-oriented data collection and analysis tools to use them in a central analysis platform, which is based on a work flow management system. An analysis work flow has been designed that, at first, identifies patients in the research database fulfilling the inclusion criteria. Then the relevant imaging data is collected. Finally the imaging data is analyzed automatically. After the successful work flow execution, the results are available for further evaluation by a physician.

As a result, the central research database has been connected successfully with automatic data collection and image analysis tools and the feasibility of our service-oriented approach has been demonstrated. In conclusion, our approach will simplify retrospective clinical trials in our department in future.

Paper Details

Date Published: 17 March 2015
PDF: 7 pages
Proc. SPIE 9418, Medical Imaging 2015: PACS and Imaging Informatics: Next Generation and Innovations, 941807 (17 March 2015); doi: 10.1117/12.2084365
Show Author Affiliations
Nina Bougatf, Heidelberg Univ. Hospital (Germany)
German Cancer Research Ctr. (Germany)
Rolf Bendl, Heilbronn Univ. (Germany)
German Cancer Research Ctr. (Germany)
Jürgen Debus, Heidelberg Univ. Hospital (Germany)


Published in SPIE Proceedings Vol. 9418:
Medical Imaging 2015: PACS and Imaging Informatics: Next Generation and Innovations
Tessa S. Cook; Jianguo Zhang, Editor(s)

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