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Proceedings Paper

Similarities and differences in ablative and non-ablative iron oxide nanoparticle hyperthermia cancer treatment
Author(s): Alicia A. Petryk; Adwiteeya Misra; Elliot J. Kastner; Courtney M. Mazur; James D. Petryk; P. Jack Hoopes
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Paper Abstract

The use of hyperthermia to treat cancer is well studied and has utilized numerous delivery techniques, including microwaves, radio frequency, focused ultrasound, induction heating, infrared radiation, warmed perfusion liquids (combined with chemotherapy), and recently, metallic nanoparticles (NP) activated by near infrared radiation (NIR) and alternating magnetic field (AMF) based platforms. It has been demonstrated by many research groups that ablative temperatures and cytotoxicity can be produced with locally NP-based hyperthermia. Such ablative NP techniques have demonstrated the potential for success. Much attention has also been given to the fact that NP may be administered systemically, resulting in a broader cancer therapy approach, a lower level of tumor NP content and a different type of NP cancer therapy (most likely in the adjuvant setting). To use NP based hyperthermia successfully as a cancer treatment, the technique and its goal must be understood and utilized in the appropriate clinical context. The parameters include, but are not limited to, NP access to the tumor (large vs. small quantity), cancer cell-specific targeting, drug carrying capacity, potential as an ionizing radiation sensitizer, and the material properties (magnetic characteristics, size and charge). In addition to their potential for cytotoxicity, the material properties of the NP must also be optimized for imaging, detection and direction. In this paper we will discuss the differences between, and potential applications for, ablative and non-ablative magnetic nanoparticle hyperthermia.

Paper Details

Date Published: 13 March 2015
PDF: 13 pages
Proc. SPIE 9326, Energy-based Treatment of Tissue and Assessment VIII, 93260K (13 March 2015); doi: 10.1117/12.2084041
Show Author Affiliations
Alicia A. Petryk, Dartmouth College (United States)
Adwiteeya Misra, Thayer School of Engineering at Dartmouth (United States)
Elliot J. Kastner, Dartmouth College (United States)
Courtney M. Mazur, Dartmouth College (United States)
James D. Petryk, Dartmouth College (United States)
P. Jack Hoopes, Dartmouth College (United States)


Published in SPIE Proceedings Vol. 9326:
Energy-based Treatment of Tissue and Assessment VIII
Thomas P. Ryan, Editor(s)

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