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Proceedings Paper

Broadband fiber optic interferometry: diagnostics by depth profiling of optical properties of biological media
Author(s): Scott C. Shukes; Robert Splinter; Faramarz Farahi; M. Yasin Akhtar Raja; G. A. Nanney; K. R. Dezern; Michelle Thompson; George P. Tatsis
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Paper Abstract

Although non-invasive methods for in-situ analysis of laser-tissue interaction are not available yet, it continues to be an area of increased interest owing to its potential. This paper describes the development of an integrated diagnostic and therapeutic laser procedure through in-situ monitoring of the optical tissue characteristics in a non-invasive manner. Biological tissues are highly scattering media. The system under development uses a broadband (white-light) interferometer that derives the scattered signals obtained from different depths of the biological medium. The tissue light signature obtained in this manner will be curve fitted to the appropriate computer simulation resulting from the optical properties particular to well defined tissues, resulting from simulations within a range of optical parameters. The beam profile of the irradiation source appears to affect the ability to distinguish between certain tissues. A single mode fiber in tissue contact produces a statistically significant different light signature for at least three myocardial tissues. However, the theoretical resolution is limited to 4 to 8 mm depth. Identification of the local optical characteristics will provide discrimination between healthy and pathological conditions in addition to real time assessment of dosimetry.

Paper Details

Date Published: 1 May 1995
PDF: 6 pages
Proc. SPIE 2396, Biomedical Optoelectronic Instrumentation, (1 May 1995); doi: 10.1117/12.208393
Show Author Affiliations
Scott C. Shukes, Univ. of North Carolina/Charlotte (United States)
Robert Splinter, Carolinas Medical Ctr. (United States)
Faramarz Farahi, Univ. of North Carolina/Charlotte (United States)
M. Yasin Akhtar Raja, Univ. of North Carolina/Charlotte (United States)
G. A. Nanney, Transform Systems Design Ltd. (United States)
K. R. Dezern, Carolinas Medical Ctr. (United States)
Michelle Thompson, Carolinas Medical Ctr. (United States)
George P. Tatsis, Carolinas Medical Ctr. (United States)

Published in SPIE Proceedings Vol. 2396:
Biomedical Optoelectronic Instrumentation
James A. Harrington; David M. Harris; Abraham Katzir, Editor(s)

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