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Proceedings Paper

Non-invasive in vivo monitoring of circulating amphotericin b using multi-wavelength photoplethysmography
Author(s): Pratik Adhikari; Wakako Eklund; Patrick D. O'Neal
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Paper Abstract

A novel multi-wavelength photoplethysmograph (PPG), previously utilized to quantify optically absorptive circulating gold nanoparticles, has demonstrated the potential to enhance therapeutic treatment predictability as pharmacokinetic metrics are provided throughout the intravenous delivery and clearance phase of amphotericin b (injected in the lipid form Abelcet®) in real-time. This report demonstrates how the PPG could be used to assess the real-time bioavailability of intravenously delivered optically-absorbing therapeutic agents. The drug currently under investigation is antifungal amphotericin b (absorption peak ~355 nm). We describe how the algorithm has been adapted to quantify the concentration of amphotericin b in the pulsatile, circulating blood based on its extinction at three wavelengths (355, 660 and 940 nm) corresponding to the peaks of amphotericin b and wavelengths for oxygen saturation measurements, respectively. We show an example of the system collecting data representing the baseline, injection, and the clearance phases. The PPG device showed a measurement range of concentrations between 0.0987 mg/mL to 0.025mg/ml in blood. An examination of the data obtained suggests that the system is well suited to sense the concentration of amphotericin b at a therapeutic dose (≈5 mg/kg/day).

Paper Details

Date Published: 9 March 2015
PDF: 6 pages
Proc. SPIE 9332, Optical Diagnostics and Sensing XV: Toward Point-of-Care Diagnostics, 93320H (9 March 2015); doi: 10.1117/12.2083798
Show Author Affiliations
Pratik Adhikari, Louisiana Tech Univ. (United States)
Wakako Eklund, Louisiana Tech Univ. (United States)
Pediatrix Medical Group of Tennessee (United States)
Patrick D. O'Neal, Louisiana Tech Univ. (United States)

Published in SPIE Proceedings Vol. 9332:
Optical Diagnostics and Sensing XV: Toward Point-of-Care Diagnostics
Gerard L. Coté, Editor(s)

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