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Proceedings Paper

Optical-resolution photoacoustic microscopy of the metabolic rate of oxygen in a mouse renal tumor model
Author(s): Chenghung Yeh; Song Hu; Jinyang Liang; Lei Li; Brian Soetikno; Zhi Hong Lu; Rebecca E. Sohn; Konstantin Maslov; Jeffrey M. Arbeit; Lihong V. Wang
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Paper Abstract

We propose using noninvasive longitudinal optical-resolution photoacoustic microscopy (L-ORPAM) to quantify blood flow flux, oxygen saturation (sO2), and thereby the metabolic rate of oxygen (MRO2), for a renal tumor model in the same mouse over weeks to months. Experiments showed that the sO2 difference between the artery and vein decreased greatly due to the arteriovenous shunting effect during tumor growth. Moreover, hypermetabolism was exhibited by an increase in MRO2.

Paper Details

Date Published: 11 March 2015
PDF: 8 pages
Proc. SPIE 9323, Photons Plus Ultrasound: Imaging and Sensing 2015, 93233H (11 March 2015); doi: 10.1117/12.2082948
Show Author Affiliations
Chenghung Yeh, Washington Univ. in St. Louis (United States)
Song Hu, Univ. of Virginia (United States)
Jinyang Liang, Washington Univ. in St. Louis (United States)
Lei Li, Washington Univ. in St. Louis (United States)
Brian Soetikno, Washington Univ. in St. Louis (United States)
Zhi Hong Lu, Washington Univ. School of Medicine (United States)
Rebecca E. Sohn, Washington Univ. School of Medicine in St. Louis (United States)
Konstantin Maslov, Washington Univ. in St. Louis (United States)
Jeffrey M. Arbeit, Washington Univ. School of Medicine (United States)
Lihong V. Wang, Washington Univ. in St. Louis (United States)


Published in SPIE Proceedings Vol. 9323:
Photons Plus Ultrasound: Imaging and Sensing 2015
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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