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Proceedings Paper

Small animal lung imaging with an in-line X-ray phase contrast benchtop system
Author(s): A. B. Garson; S. Gunsten; H. Guan; S. Vasireddi; S. Brody; M. A. Anastasio
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Paper Abstract

We present the results from a benchtop X-ray phase-contrast (XPC) method for lung imaging that represents a paradigm shift in the way small animal lung imaging is performed. In our method, information regarding airway microstructure that is encoded within speckle texture of a single XPC radiograph is decoded to spatially resolve changes in lung properties such as microstructure sizes, air volumes, and compliance, to name a few. Such functional information cannot be derived from conventional lung radiography or any other 2D imaging modality. By computing these images at different time points within a breathing cycle, dynamic functional imaging can be potentially achieved without the need for tomography.

Paper Details

Date Published: 18 March 2015
PDF: 7 pages
Proc. SPIE 9412, Medical Imaging 2015: Physics of Medical Imaging, 94120L (18 March 2015); doi: 10.1117/12.2082898
Show Author Affiliations
A. B. Garson, Washington Univ. in St. Louis (United States)
S. Gunsten, Washington Univ. School of Medicine (United States)
H. Guan, Washington Univ. in St. Louis (United States)
S. Vasireddi, Case Western Reserve Univ. (United States)
S. Brody, Washington Univ. School of Medicine (United States)
M. A. Anastasio, Washington Univ. in St. Louis (United States)


Published in SPIE Proceedings Vol. 9412:
Medical Imaging 2015: Physics of Medical Imaging
Christoph Hoeschen; Despina Kontos, Editor(s)

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