Share Email Print
cover

Proceedings Paper

Photodynamic therapy application of PAMAM-porphyrin molecule on stomach cancer cells
Author(s): Tugba Kiris; Mehmet Necmi Burgucu; Tugba Sagir; Mehmet Senel; Sevim Isik; Gamze Bölük-basi Ates; Hasim Ozgur Tabakoglu
Format Member Price Non-Member Price
PDF $14.40 $18.00

Paper Abstract

In this study, effect of a novel LED-based light source developed for 96-well-plates cell culture applications, was tried on AGS stomach cancer cell line, in combination with Poly(amido amine) (PAMAM) modified – porhyrin molecule. For each 4 generation of modified PpIX molecule 5 different concentrations tried. According to results PAMAM molecule doesnt have any photosensitizer property also didn’t show any toxic effect even if higher concentrations. Morphology and real time monitoring analysis results hold up each other and confirmed that, PpIX molecules with and without modificated high concentrations (>100μM) caused cell death via toxicicity this reason optimal concentration for PAMAM modified PpIX should be between 25 - 50 μm concentration .

Paper Details

Date Published: 2 March 2015
PDF: 6 pages
Proc. SPIE 9308, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIV, 93080X (2 March 2015); doi: 10.1117/12.2082731
Show Author Affiliations
Tugba Kiris, Fatih Univ. (Turkey)
Mehmet Necmi Burgucu, Fatih Univ. (Turkey)
Tugba Sagir, Fatih Univ. (Turkey)
Mehmet Senel, Fatih Univ. (Turkey)
Sevim Isik, Fatih Univ. (Turkey)
Gamze Bölük-basi Ates, Bogazici Univ. (Turkey)
Hasim Ozgur Tabakoglu, Fatih Univ. (Turkey)


Published in SPIE Proceedings Vol. 9308:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIV
David H. Kessel; Tayyaba Hasan, Editor(s)

© SPIE. Terms of Use
Back to Top