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Proceedings Paper

Plasmonic nanoparticle interaction with cell membrane for diagnostic applications
Author(s): Sumana Das; Akshata Arikady; Ramakrishna Vasireddi; Krishna Harika; Manish Konnur; Gopalkrishna M. Hegde; D. Roy Mahapatra
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Paper Abstract

Optofluidic schemes of inhibition, transport and activation by carrier molecules through cell membrane have interesting applications. Through plasmonic excitation of nanoparticles integrated in microfluidic channel, we observe cell membrane structural changes. Related phenomena are studied in situ in a microfluidic channel via fluorescence imaging. Detailed analysis is carried out to understand the possible application of this scheme in optically induced transport and expression of cell membrane protein. Optical properties of the cells undergoing plasmonic transport are monitored and correlated to cell expression assay. Plasmonic charge transport and optical transmission are measured in the microfluidic lab-on-chip along with in-situ imaging.

Paper Details

Date Published: 2 March 2015
PDF: 6 pages
Proc. SPIE 9310, Frontiers in Biological Detection: From Nanosensors to Systems VII, 93100A (2 March 2015); doi: 10.1117/12.2082598
Show Author Affiliations
Sumana Das, Indian Institute of Science (India)
Akshata Arikady, Indian Institute of Science (India)
Ramakrishna Vasireddi, Indian Institute of Science (India)
Krishna Harika, Indian Institute of Science (India)
Manish Konnur, Indian Institute of Science (India)
Gopalkrishna M. Hegde, Indian Institute of Science (India)
D. Roy Mahapatra, Indian Institute of Science (India)


Published in SPIE Proceedings Vol. 9310:
Frontiers in Biological Detection: From Nanosensors to Systems VII
Benjamin L. Miller; Philippe M. Fauchet; Brian T. Cunningham, Editor(s)

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