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Proceedings Paper

High-definition Fourier transform infrared spectroscopic imaging of breast tissue
Author(s): L. Suzanne Leslie; Andre Kadjacsy-Balla; Rohit Bhargava
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Paper Abstract

Breast cancer diagnosis relies on staining serial sections of a biopsy in a process that can be time intensive and costly. Fourier transform infrared imaging (FT-IR) is a non-destructive, label-free chemical imaging technique that uses the vibrational structure of the biological molecules of the sample to provide contrast for images at any absorption peak in the mid-infrared. The full potential of spectroscopic imaging has been limited by the spatial resolution provided by most commercial instruments. By increasing the magnification and numerical aperture of the microscope, image pixel sizes on the order of 1.1 micron can be achieved, allowing HD FT-IR spectroscopic imaging to provide high quality images that could aid in histopathology, diagnosis, and studies of breast cancer progression.

Paper Details

Date Published: 19 March 2015
PDF: 8 pages
Proc. SPIE 9420, Medical Imaging 2015: Digital Pathology, 94200I (19 March 2015); doi: 10.1117/12.2082461
Show Author Affiliations
L. Suzanne Leslie, Beckman Institute for Advanced Science and Technology (United States)
Univ. of Illinois at Urbana-Champaign (United States)
Andre Kadjacsy-Balla, Univ. of Illinois at Chicago (United States)
Univ. of Illinois Cancer Ctr. (United States)
Rohit Bhargava, Beckman Institute for Advanced Science and Technology (United States)
Univ. of Illinois at Urbana-Champaign (United States)
Univ. of Illinois Cancer (United States)


Published in SPIE Proceedings Vol. 9420:
Medical Imaging 2015: Digital Pathology
Metin N. Gurcan; Anant Madabhushi, Editor(s)

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