Share Email Print
cover

Proceedings Paper

Developing hyperpolarized silicon particles for advanced biomedical imaging applications
Author(s): Nicholas Whiting; Jingzhe Hu; Pamela Constantinou; Niki Zacharias Millward; James Bankson; David Gorenstein; Anil Sood; Daniel Carson; Pratip Bhattacharya
Format Member Price Non-Member Price
PDF $14.40 $18.00

Paper Abstract

Silicon-based nanoparticles are ideally suited as biomedical imaging agents, due to their biocompatibility, biodegradability, and simple surface chemistry that is amenable to drug loading and targeting. A method of hyperpolarizing silicon particles using dynamic nuclear polarization (DNP), which increases magnetic resonance imaging (MRI) signals by 4-5 orders of magnitude through enhanced nuclear spin alignment, has recently been developed and shown viable as a contrast agent for in vivo MRI. Naturally occurring electronic defects on the particle surface obviate the need for exogenous radicals, and the enhanced spin polarization lasts for significantly longer than other hyperpolarized agents (tens of minutes, instead of <1 minute for other species). We report our recent advances in determining the MR characteristics of hyperpolarized silicon particles, which could lead to non-invasive, non-radioactive molecular targeted imaging of various cancer systems. A variety of particle sizes (20 nm-2 μm) were found to have hyperpolarized relaxation times ranging from ~10-50 minutes. The addition of various functional groups to the particle surface, including biocompatible polymers, aptamers, and antibodies had no effect to the hyperpolarization dynamics or relaxation times, and appear to satisfactorily survive the harsh temperature conditions of DNP. Preliminary in vivo studies examined a variety of particle administration routes in mice, including intraperitoneal, tail vein, and rectal injections, as well as oral gavage. Ongoing experiments include targeted molecular imaging in orthotopic murine models of ovarian and colorectal cancers.

Paper Details

Date Published: 17 March 2015
PDF: 8 pages
Proc. SPIE 9417, Medical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging, 941702 (17 March 2015); doi: 10.1117/12.2082252
Show Author Affiliations
Nicholas Whiting, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Jingzhe Hu, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Rice Univ. (United States)
Pamela Constantinou, Rice Univ. (United States)
Niki Zacharias Millward, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
James Bankson, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
David Gorenstein, The Univ. of Texas Health Science Ctr. at Houston (United States)
Anil Sood, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Daniel Carson, Rice Univ. (United States)
Pratip Bhattacharya, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)


Published in SPIE Proceedings Vol. 9417:
Medical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging
Barjor Gimi; Robert C. Molthen, Editor(s)

© SPIE. Terms of Use
Back to Top