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Proceedings Paper

Importance of fluence rate in photodynamic therapy with ALA-induced PpIX and BPD-MA in a rat bladder tumor model
Author(s): Seiichi Iinuma; Georges A. Wagnieres; Kevin T. Schomacker; Mike Bamberg; Tayyaba Hasan
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Paper Abstract

Oxygen dependent phototoxicity was investigated in vivo in an orthotopic rat bladder tumor model. Two photosensitizers, benzoporphyrin derivative monoacid ring A and 5-aminolevulinic acid-induced protoporphyrin IX were studied. For a given cumulative light dose of 30 J/cm2, enhanced tumor destruction was obtained for both photosensitizers by either using a low fluence rate or fractionated light delivery mode. These observations may be attributed to rapid local oxygen consumption during photochemical reactions.

Paper Details

Date Published: 1 May 1995
PDF: 5 pages
Proc. SPIE 2392, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy IV, (1 May 1995); doi: 10.1117/12.208182
Show Author Affiliations
Seiichi Iinuma, Keio Univ. School of Medicine (Japan)
Georges A. Wagnieres, Ecole Polytechnique Federal de Lausanne (Switzerland)
Kevin T. Schomacker, Wellman Labs. of Photomedicine (United States)
Massachusetts General Hospital (United States)
Harvard Medical School (United States)
Mike Bamberg, Wellman Labs. of Photomedicine (United States)
Massachusetts General Hospital (United States)
Harvard Medical School (United States)
Tayyaba Hasan, Wellman Labs. of Photomedicine (United States)
Massachusetts General Hospital (United States)
Harvard Medical School (United States)


Published in SPIE Proceedings Vol. 2392:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy IV
Thomas J. Dougherty, Editor(s)

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