Share Email Print
cover

Proceedings Paper

Detection of high-grade atypia nuclei in breast cancer imaging
Author(s): Henri Noël; Ludovic Roux; Shijian Lu; Thomas Boudier
Format Member Price Non-Member Price
PDF $14.40 $18.00

Paper Abstract

Along with mitotic count, nuclear pleomorphism or nuclear atypia is an important criterion for the grading of breast cancer in histopathology. Though some works have been done in mitosis detection (ICPR 2012,1 MICCAI 2013,2 and ICPR 2014), not much work has been dedicated to automated nuclear atypia grading, especially the most difficult task of detection of grade 3 nuclei. We propose the use of Convolutional Neural Networks for the automated detection of cell nuclei, using images from the three grades of breast cancer for training. The images were obtained from ICPR contests. Additional manual annotation was performed to classify pixels into five classes: stroma, nuclei, lymphocytes, mitosis and fat. At total of 3,000 thumbnail images of 101 × 101 pixels were used for training. By dividing this training set in an 80/20 ratio we could obtain good training results (around 90%). We tested our CNN on images of the three grades which were not in the training set. High grades nuclei were correctly classified. We then thresholded the classification map and performed basic analysis to keep only rounded objects. Our results show that mostly all atypical nuclei were correctly detected.

Paper Details

Date Published: 17 March 2015
PDF: 6 pages
Proc. SPIE 9420, Medical Imaging 2015: Digital Pathology, 94200R (17 March 2015); doi: 10.1117/12.2081793
Show Author Affiliations
Henri Noël, Image and Pervasive Access Lab. (Singapore)
Ludovic Roux, Image and Pervasive Access Lab. (Singapore)
Shijian Lu, Image and Pervasive Access Lab. (Singapore)
Thomas Boudier, Image and Pervasive Access Lab. (Singapore)
BioInformatics Institute (Singapore)


Published in SPIE Proceedings Vol. 9420:
Medical Imaging 2015: Digital Pathology
Metin N. Gurcan; Anant Madabhushi, Editor(s)

© SPIE. Terms of Use
Back to Top